| 1st January 2000 | Y2K passes without serious failures, despite fears of the Millennium Bug breaking down computers. |
| 11th January 2000 | The trawler Solway Harvester sinks off the Isle of Man. |
| 31st January 2000 | Dr. Harold Shipman is found guilty of murdering fifteen patients between 1995 and 1998 and is subsequently sentenced to life imprisonment. |
| 17th February 2000 | Microsoft releases Windows 2000. |
| 23rd February 2000 | Sir Stanley Matthews, English footballer (b. 1915) dies |
| 26th March 2000 | Vladimir Putin is elected President of Russia. |
| 31st March 2000 | Myra Hindley loses a High Court appeal against her life imprisonment sentence. |
| 22nd April 2000 | Brazil officially celebrates its 500th anniversary; albeit with protests, especially from native and black populations. |
| 12th May 2000 | The Tate Modern Gallery opens in London. |
| 2nd July 2000 | France beats Italy 2-1 to win ‘Euro 2000’ with a Golden Goal. |
| 18th July 2000 | Alex Salmond resigns as leader of the Scottish National Party. |
| 18th July 2000 | Sussex police launch a murder investigation after the body of a 9-year-old girl found near Pulborough is confirmed to be that of Sarah Payne, who was reported missing on 1st July. |
| 25th July 2000 | Air France Flight 4590, a Concorde aircraft, crashes into a hotel in Gonesse just after take-off in Paris. All 109 passengers are killed, in addition to four people from the hotel. |
| 7th September 2000 | The United Kingdom fuel protests begin. Refineries are blockaded and therefore supply to the country's network of petrol stations is halted. |
| 15th September 2000 | The 2000 Summer Olympics begin in Sydney, Australia. |
| 29th September 2000 | The Long Kesh prison in Northern Ireland is closed. |
| 21st October 2000 | Reginald “Reggie” Kray, leading figure in organised crime in London (b. 1933) dies. |
| 3rd November 2000 | Widespread flooding occurs throughout England and Wales after days of heavy rain. |
| 7th November 2000 | A criminal gang raids the Millennium Dome to steal The Millennium Star diamond, but police surveillance catches them in the act. |
| 31st December 2000 | The Millennium Dome closes its doors one year to the day of its opening. |